Search results for " Freeze-drying"
showing 3 items of 3 documents
Spray-Drying, Solvent-Casting and Freeze-Drying Techniques: a Comparative Study on their Suitability for the Enhancement of Drug Dissolution Rates.
2019
Purpose Solid dispersions (SDs) represent the most common formulation technique used to increase the dissolution rate of a drug. In this work, the three most common methods used to prepare SDs, namely spray-drying, solvent-casting and freezedrying, have been compared in order to investigate their effect on increasing drug dissolution rate. Methods Three formulation strategies were used to prepare a polymer mixture of polyvinyl-alcohol (PVA) and maltodextrin (MDX) as SDs loaded with the following three model drugs, all of which possess a poor solubility: Olanzapine, Dexamethasone, and Triamcinolone acetonide. The SDs obtained were analysed and compared in terms of drug particle size, drug-lo…
Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review
2021
The fabrication of 3D scaffolds is under wide investigation in tissue engineering (TE) because of its incessant development of new advanced technologies and the improvement of traditional processes. Currently, scientific and clinical research focuses on scaffold characterization to restore the function of missing or damaged tissues. A key for suitable scaffold production is the guarantee of an interconnected porous structure that allows the cells to grow as in native tissue. The fabrication techniques should meet the appropriate requirements, including feasible reproducibility and time- and cost-effective assets. This is necessary for easy processability, which is associated with the large …
Simple techniques suitable for long-term storage of Plasmopara viticola
2006
Summary. Propagules of Plasmopara viticola or fragments of P. viticola infected host tissue were stored by three techniques, freezing at –25°C, dehydration with CaCl2, and freeze-drying. Viability tests were performed periodically until exhaustion of the testing sample. P. viticola samples that were frozen at -25°C remained viable for eight years, whereas the CaCl2 dehydrated samples remained viable for eight and a half years. Freeze-drying was the most successful long-term storage method, being able to preserve samples for almost 21 years.